Learn Cognitive Changes Following Cancer Treatment

Some malignancies and treatments can cause cognitive alterations that impair how we think, learn, process and recall information. These changes can impact many facets of life, including the capacity to work or even do daily duties. Determine whether you are at a higher risk of cognitive changes.

Learn Cognitive Changes Following Cancer Treatment

Cognitive changes can occur abruptly (acute onset) or gradually over time (gradual onset). Adults and children may experience distinct types of changes. We’ll concentrate on cognitive abnormalities in adults with cancer in this section. If you have any questions about children who are experiencing cognitive changes, consult with your health care team.

• Tumors in the central nervous system (CNS), which includes the brain and spinal cord;

• Treatments provided directly to the CNS;

• Treatments administered when critically unwell.

• Concurrent administration of chemo and radiation to the brain. • Chemotherapy is administered to the spinal fluid following radiation.

Higher-dose chemotherapy and the use of immunotherapy to stimulate the immune system can sometimes cause cognitive problems. Those with brain cancer may also have cognitive abnormalities due to the tumor or its treatment. While cognitive changes caused by brain surgery are frequently instantaneous, alterations caused by radiation and chemotherapy might arise gradually over time. Some alterations that occur after cancer are modest and will pass. Other cognitive impairments may be more visible and irreversible. Discuss any symptoms or signs with your health care team.

Cognitive Changes and Their Symptoms

Discuss with your health care staff these potential reasons for cognitive issues. This will assist you in receiving the proper diagnosis and treatment.

Mild cognitive alterations (“Chemo-brain”)

Following chemotherapy, survivors may have impaired memory or concentration capacity. This type of minor cognitive shift is called “chemo-brain.” Even slight cognitive alterations can interfere with daily life and work abilities.

• Difficulty concentrating and multitasking are symptoms.

• Difficulties remembering recent occurrences.

• Difficulty finishing duties

• Slower processing speed.

• Impaired capacity to think clearly.

Tumors’ impact on cognition

A brain tumor or cancer can harm healthy cells and cause cognitive problems. Chemotherapy, radiation therapy, and surgery are all treatments designed to remove or destroy cancer cells. However, they can also harm some of the surrounding healthy cells directly or indirectly by affecting the brain. Depending on the extent of the damage, there may be apparent symptoms such as changes in thinking, memory, speech, visual-spatial issues, and behavior.

Changes in cognition that occur suddenly (delirium)

Acute onset cognitive alterations are those that happen all of a sudden. Some acute alterations, such as delirium, appear and disappear with no discernible pattern. This can occur after treatment with some medicines and chemotherapeutic treatments and is potentially reversible.

• Fluctuating alertness and orientation are symptoms.

• Difficulty focusing.

• Low level of consciousness or the person appears “out of it.”

• The individual is unaware of what is happening around them.

• Disturbing sleep habits, such as being awake at night and sleeping throughout the day.

• Agitation.

• Confusion.

• Impaired memory.

• Aggressive, loud conduct.

• Hallucinations or seeing things that aren’t there.

• Disorientation or the person is unsure where they are.

• Sedation or bewilderment, as well as quiet, passive demeanor.

Cognitive changes that appear gradually (dementia)

In this document, dementia refers to cognitive abnormalities caused by medical diseases other than Alzheimer’s. Gradual onset cognitive changes occur gradually over time and may be permanent. Dementia symptoms may not occur until active cancer therapy is completed.

Symptoms include

• Impaired memory.

• Difficulties with abstract reasoning and multitasking

• Poor decision-making (makes unsafe decisions).

• Poor decision-making.

• Personality shifts (may become moody or upset without an apparent cause).

• Difficulty solving problems and following directions.

• Disorientation (being unsure of where they are). • Changes in cognition and conduct have a detrimental impact on professional or social life and independence.

Other cognitive alterations that cancer survivors experience

Chemotherapy can produce exhaustion and anemia, contributing to cognitive issues, particularly attention. A survivor may also encounter other diseases that produce cognitive abnormalities unrelated to cancer or therapy. Some of these problems can be reversed, while others cannot.

• Anxiety is one condition.

• Depression.

• Electrolyte imbalances

• Hypoxia (low oxygen levels).

• Other brain disorders, such as Alzheimer’s or Parkinson’s disease.

• Thyroid issues.

• Severe nutritional issues.

When Do Cognitive Changes Take Place?

Cognitive changes might develop at any time during your cancer treatment. They can be the first sign of a brain tumor. These alterations can also occur after cancer therapy or when taking specific drugs.

Chemo brain can happen during or after chemotherapy.

• Delirium can strike unexpectedly during therapy. Delirium usually occurs due to a known cause, such as chemotherapy, and it is frequently reversible.

• Dementia caused by cancer therapy develops gradually over time, usually after the treatment is finished. It may be more challenging to recognize than delirium and may not have a single apparent cause. Dementia can appear as soon as three months following brain irradiation.

• After surgery to remove a brain tumor, symptoms of dementia (such as memory loss) can arise 48 months or longer after completion of radiation therapy.

Managing Cognitive Changes

The cause of cognitive alterations determines whether they will improve or be permanent. Acute cognitive problems (delirium) caused by certain medications often improve after the drug is discontinued. Chronic alterations (such as dementia) are frequently irreversible.

However, some drugs may improve cognitive performance, and there may be some improvement if the underlying source of the issues is addressed. Keep a record of any problems you encounter if you detect changes in your thinking, memory, or behavior.

Request that your family or friends keep an eye out for any changes. Inform your healthcare team as soon as possible about these symptoms. Request a neuropsychological evaluation with a neuropsychologist to determine the nature, severity, and potential reasons for your cognitive abnormalities. A neuropsychologist may recommend measures to help you function better. Treating the underlying illness frequently reduces or eliminates cognitive issues.